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October 1, 2025Emerging infectious diseasesOpen Access

Emergence and Polyclonal Dissemination of blaNDM-7–Carrying InX3 Plasmid in Enterobacter cloacae Complex, France, 2021–2023

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Authors

IRInès RezzougInsermDGDelphine GirlichInsermABA. BirerCentre Hospitalier Universitaire de Clermont-Ferrand

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Implication

Analysis reveals the spread of blaNDM-7 gene on InX3 plasmids in Enterobacter cloacae, indicating critical need for enhanced monitoring.

Key Points

  • The blaNDM-7 gene was detected on InX3 plasmids, indicating a concerning spread of antimicrobial resistance.
  • Among 3,367 isolates, the emergence of blaNDM-7 was systematically linked to closely related plasmids.
  • Enhanced surveillance of antimicrobial resistance is crucial to address the growing threat from these isolates.
  • The presence of virulence factors on the plasmids raises concerns about the potential impact on public health.

Cite This Study

Rezzoug et al. (2025) studied this question.

synapsesocial.com/papers/68dd89e6fe798ba2fc497fe8https://doi.org/10.3201/eid3110.250830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Klebsiella pneumoniae sequence type 147: a high-risk clone increasingly associated with plasmids carrying both resistance and virulence elements2024 · 24 citations
  2. 2Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 20222023 · 52 citations
  3. 3Klebsiella pneumoniae ST147 harboring bla NDM-1 , multidrug resistance and hypervirulence plasmids2024 · 23 citations
  4. 4Dissemination of NDM-1-Producing Enterobacteriaceae Mediated by the IncX3-Type Plasmid2015 · 49 citations
  5. 5Worldwide Dissemination of the NDM-Type Carbapenemases in Gram-Negative Bacteria2014 · 505 citations