This guide aims to clarify ambiguities in the MRC Scale for assessing functional deterioration in prion diseases, improving scoring consistency among caregivers and experts.
Background The prion diseases (PrD) are a group of progressive, fatal, neurodegenerative diseases, for which the Medical Research Council Prion Disease Rating Scale (MRC Scale) can be used to assess patients' functional deterioration. Findings from previous qualitative interviews with caregivers and clinical experts identified potential ambiguities in the scale that could lead to inconsistent scoring within and/or between raters.
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Pulido et al. (2025) studied this question.
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