Systematic review highlights resistance rates to extended-spectrum cephalosporins in Neisseria gonorrhoeae globally, indicating urgent public health needs.
The global emergence of antibiotic resistance in Neisseria gonorrhoeae (NG) infections poses a critical public health challenge. This study aimed to evaluate global resistance rates to extended-spectrum cephalosporins (ESCs) in N. gonorrhoeae , considering factors such as time, geography, antimicrobial susceptibility testing (AST), and resistance interpretation. A systematic review and meta-analysis (from 1988 to 2025) of 252 studies from 71 countries reported a weighted pooled resistance rate (WPR) of ≤ 2.5% for ESCs. Significant temporal variation in ESCs-resistant isolates ( P < 0.05) underscores the dynamic nature of resistance development. Significantly, there was a difference in penicillin resistance rates between countries/ continents, and AST ( P < 0.001). These findings emphasize the urgent need for effective antimicrobial stewardship, enhanced contact tracing, and comprehensive monitoring systems to combat antimicrobial resistance in gonococcal infections.
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Alhusseini et al. (2025) studied this question.
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