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October 1, 2025Frontiers in GeneticsOpen Access

Identification and validation of calcium signaling pathway-related biomarkers in T1 and T2 lymph node metastatic gastric cancer

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Authors

MCMingzhi CaiXNXinyang NieFCFenglin Cai

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Overview

Cox regression analysis identified RET as a key biomarker in T1 and T2 gastric cancer, indicating potential therapeutic pathways.

Key Points

  • RET was identified as a significant biomarker linked to lymph node status in gastric cancer.
  • Patients with lymph node-positive gastric cancer exhibited significant differences in immune scores compared to negative cases.
  • Enrichment analysis revealed 36 distinct pathways differentiating lymph node-positive and negative groups.
  • The study highlights RET's potential for targeted therapies in lymph node metastatic gastric cancer.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68dd91cbfe798ba2fc49884dhttps://doi.org/10.3389/fgene.2025.1653700
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