Optimization of Polyphenol Extraction from Two Ziziphus Species via Central Composite Design-Response Surface Methodology: In Vitro Screening for Antioxidant, Antidiabetic, and Anti-Glycation Potentials

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This analysis demonstrates antioxidant and antidiabetic properties in Ziziphus species, implying effective extraction methods.

Significant antioxidant activity was observed in Z. mauritiana, with higher DPPH and ABTS values than Z. spina-christi.
The total phenolic content reached 120.59 mg GAE/g DW for Z. mauritiana and 104.77 mg GAE/g DW for Z. spina-christi.
Central composite design-response surface methodology proved effective in optimizing extraction parameters.
In vitro assays indicated promising anti-glycation effects, highlighting potential applications in managing diabetes.

Alkanad et al. (2025) studied this question.

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