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October 1, 2025Tropical Journal of Natural Product ResearchOpen Access

Molecular Docking Study of Standardized Lime (Citrus aurantiifolia) Peel Decoction as an Antidiabetic Herbal

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Authors

YDYesi DesmiatyFXFrancis XavierHAHanifah Agusti

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Overview

Molecular docking reveals flavonoid compounds inhibit α-glucosidase and SGLT-2 in diabetes models, indicating potential uses.

Key Points

  • Molecular docking shows rutin inhibits α-glucosidase, α-amylase, and DPP-4, reinforcing its antidiabetic potential.
  • Compounds including hesperidin and naringin exhibited inhibitory effects on key diabetes-related enzymes like SGLT-2.
  • Ultrasonic-assisted extraction was utilized to obtain compounds from Citrus aurantiifolia peels for analysis.
  • ADMET predictions indicate active compounds in citrus have limited absorption but show no toxicity.

Cite This Study

Desmiaty et al. (2025) studied this question.

synapsesocial.com/papers/68dd91cbfe798ba2fc4988f0https://doi.org/10.26538/tjnpr/v9i9.65
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Also Consider

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