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October 1, 2025Turkish Journal of Clinics and LaboratoryOpen Access

Clinical investigation of patients with positive antineutrophil cytoplasmic antibodies (ANCA) test for autoimmunity and vasculitis

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Authors

ESEmrah SalmanATAlparslan Toyran

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Overview

Retrospective cohort analysis of 218 ANCA-positive patients shows varied organ involvement in AAV, suggesting diagnostic indicators.

Key Points

  • Patients with AAV have higher joint and skin involvement compared to non-autoimmune individuals, indicating disease severity.
  • Hypertension and chronic renal failure are more prevalent among AAV and non-autoimmune patients compared to autoimmune disease patients.
  • AAV diagnoses are associated with elevated CRP and complement levels, suggesting inflammation in these patients.
  • A strong correlation exists between ANCA titers, especially proteinase 3, and clinical diagnoses of AAV.

Cite This Study

Salman et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc498fd9https://doi.org/10.18663/tjcl.1679367
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