This approach demonstrates the synthesis of crotyl esters through oxa-michael addition and reduction, indicating effectiveness for complex structure formation.
The synthesis of 4‐tetrahydropyranyl crotyl esters has been conveniently achieved by merging a tandem Oxa‐Michael cyclization/Weinreb amide reduction and a subsequent Wittig‐Horner olefination. The procedure was also applied to the access to a parent benzofuran derivative.
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Hiebel et al. (2025) studied this question.
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