What type of study is this?

This is a RCT study (also classified as: Phase 3).

October 1, 2025VaccinesOpen Access

Immune Persistence Following a Single Dose of Varicella Vaccine: 5-Year and 8-Year Follow-Up of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial

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Randomized trial shows strong immune persistence in children post-varicella vaccination, suggesting monitoring for potential booster needs.

Varicella antibody levels remained stable from 5 to 8 years post-vaccination, indicating effective long-term immune persistence.
After 5 years, seropositive rates for VarV group were 100% at ≥1:4, while the placebo group was at 80.83%, indicating significant protection.
This randomized controlled trial analyzed immune responses using FAMA method and included 487 participants for 5-year and 422 for 8-year follow-ups.
The findings suggest that while there is good immune persistence, antibody levels decline over time, highlighting the need for potential revaccination.

Wang et al. (2025) studied this question.

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Randomized trial shows strong immune persistence in children post-varicella vaccination, suggesting monitoring for potential booster needs.