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October 1, 2025Open Access

In Silico discovery and design of molecular glues as a new strategy for development of non-peptidic, small-molecule agonists of GLP-1 receptor

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Authors

LTLiang TangHZHaiyan Zhao

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Overview

Virtual screening identifies molecular glues that enhance GLP-1 receptor signaling, suggesting new small-molecule agonists may improve treatment for type 2 diabetes and obesity.

Key Points

  • Molecular glues can enhance the assembly of GLP-1R and G-protein, leading to potential allosteric activation.
  • Virtual screening identified candidate compounds with binding affinities comparable to peptide-based drugs, like orforglipron.
  • The approach utilizes a new strategy to design small-molecule GLP-1R agonists, addressing limitations of existing peptidic medications.
  • Molecular hybridization has resulted in compounds with improved binding properties, expanding therapeutic options for metabolic disorders.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499786https://doi.org/10.26434/chemrxiv-2025-k2gjf
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural basis for chemotype diversity in small molecule GLP-1 receptor agonist drug discovery2025
  2. 2Exploring GLP-1 peptide bound to its receptor, GLP-1R, through MD simulations and MMGBSA: Implications for rational drug design2026
  3. 3Unveiling the Activation Mechanism of Glucagon-Like Peptide-1 Receptor by an Ago-Allosteric Modulator via Molecular Dynamics Simulations2026
  4. 4Oral Small-Molecule GLP-1 Receptor Agonists: Lessons from Clinical Candidates and a Blueprint for Next-Generation Design2026
  5. 5Novel Small Molecule GLP-1R Agonists Based on 1H-Benzo[d]imidazole-5-Carboxylic Acid Scaffold2026