Amoxicillin-Induced Neutrophilic Dermatosis of the Dorsum of the Hand

Neutrophilic dermatosis of the dorsum of the hand (NDDH) is a rare skin condition characterized by acute onset painful erythematous and violaceous papules localized to the dorsum of the hand with histological evidence of dense neutrophilic infiltrate without evidence of vasculitis. This condition is most commonly seen in middle aged females and is often associated with fever and an upregulation of inflammatory markers. NDDH is also characterized by its excellent response to corticosteroid therapy. This condition is often the result of an underlying inflammatory condition or malignancy, but it can also be secondary to drug administration. This case report describes a 72-year-old female with a history of collagenous colitis who presented with NDDH following treatment with amoxicillin.