Observational analysis reveals protective properties of ganoderma lucidum against hepatic lipotoxicity from high-fat diet, indicating a potential therapeutic use.
Background and objectivesA long-term high-fat diet (HFD) exerts lipotoxic effects on multiple organs, particularly the liver, leading to metabolic diseases. This study aimed to delineate the dynamic effects of HFD on lipid metabolism, elucidate the mechanisms underlying hepatic lipotoxicity, and investigate the protective effects of Ganoderma lucidum against lipotoxicity both in vitro and in vivo.
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Cao et al. (2025) studied this question.
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