This analysis reveals positive bounded solutions and stability conditions in protein dynamics models, indicating feedback mechanisms are crucial.
In this paper, we establish the existence of a positive, bounded solution for a class of parabolic partial differential equations with nonlinear boundary conditions, where the boundary conditions depend on the solution on the boundary at a time τ≥ 0 in the past. These equations model the production dynamics of a protein species by a single cell, where a feedback mechanism downregulates the protein's production. Furthermore, we analyze the stability of a non-trivial steady-state solution and provide sufficient conditions on the nonlinearity parameter, boundary flux, and time delay that ensure the occurrence of a Hopf bifurcation.
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Boregowda et al. (2025) studied this question.
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