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October 2, 2025Current Pharmaceutical Design

Exploring the Mechanism of Bu Zhong Yi Qi Decoction in Treating Sepsis-induced Acute Lung Injury based on Network Pharmacology and Experimental Verification

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Authors

JLJiaxin LiJZJiayao ZhaoZSZack Shan

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Overview

Research explores the impact of Buzhong Yiqi Decoction on inflammation and oxidative stress in sepsis-induced acute lung injury.

Key Points

  • Buzhong Yiqi Decoction significantly reduces inflammatory factors and oxidative stress in sepsis-induced acute lung injury.
  • Molecular docking shows high binding activity of core components with key targets like TNF and AKT, indicating effective action.
  • Through network pharmacology, multiple databases identified relevant genes and pathways related to the treatment of sepsis-induced acute lung injury.
  • In vivo studies demonstrate Buzhong Yiqi Decoction's ability to decrease inflammation and improve lung tissue health in model mice.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a21235https://doi.org/10.2174/0113816128397243250902131510
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