Supplementary Figure 7 from Depleting the Action of EZH2 through PI3K–mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer

Key Points

High PIK3R2 expression correlates with reduced survival in triple-negative breast cancer patients.
A significant association was found between PIK3R2 gene expression and the response to immunotherapy.
Targeting EZH2 via PI3K–mTOR pathways could provide an effective strategy against metastasis.
Clinical data highlight the urgency of addressing immunotherapy resistance in TNBC treatment.

Analysis shows PI3K–mTOR inhibition affects survival in TNBC patients, suggesting novel therapeutic approaches.

Supplementary Figure 7. Associations between PIK3R2 gene expression and survival probability amongst TNBC patient cohorts.

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Melino et al. (2025) studied this question.

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