Prognostic factors and outcomes of extremity necrotising fasciitis in Singapore

Necrotising fasciitis (NF) is a rapidly progressive infection that spreads across the fascial planes, leading to tissue necrosis and severe systemic toxicity.1 In Singapore, Wong et al. conducted a retrospective study on a cohort of 89 patients in 2004 and found that the misdiagnosis rate was 85%, amputation rate was 23% and mortality rate was 21%.2,3 However, since these early studies, there has been a paucity of data on NF in the Singapore context, despite changing antimicrobial resistance patterns and evolving management approaches.2,3 To address this gap, a 17-year retrospective cohort study was conducted in the National University Hospital (NUH) in Singapore. The aim was to report an update of the clinical/microbiological profile, adverse outcomes (amputation/mortality) rates and identify predictive factors for adverse outcomes in patients with extremity NF.