Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry

Q: What type of study is this?

This is a Quantitative Study study.

James R. Lloyd; Arppana Sara Varughese; Parth Kapoor; Katharina Duerr; Hsin‐Yung Yen; Ali Jazayeri; Jonathan T. S. Hopper; Neil J. Oldham

doi:10.1039/d5sc05107j

January 1, 2025Chemical ScienceOpen Access

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry

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Key Points

The study identifies structural changes in the β-1 adrenergic receptor upon ligand binding, enhancing understanding of its dynamics.
Using mass spectrometry, the analysis uncovers binding specificities and regional differences across multiple receptor sites.
Carbene footprinting techniques enable detailed inspection of ligand interactions, unveiling critical insights into GPCR behavior.
Investigating the β-1 adrenergic receptor offers potential for novel therapeutic strategies targeting cardiovascular conditions.

Implication

This analysis reveals ligand binding dynamics at the β-1 adrenergic receptor, suggesting implications for GPCR-targeted therapies.

Abstract

G protein coupled receptors (GPCRs) control many physiological processes and are major targets for therapeutic intervention. Transmembrane proteins, such as G protein–coupled receptors (GPCRs), are inherently flexible and dynamic and...

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Cite This Study

Lloyd et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3a83cbc991d0a228f9 https://doi.org/10.1039/d5sc05107j

View Full Paper

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Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry

Key Points

Implication

Abstract

Discussion

Cite This Study

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