Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

Immunotherapy, despite its notable therapeutic potential in cancer and inflammatory diseases, still faces challenges in clinical efficacy due to the complexity of tumor or inflammatory microenvironment. Nanogels (NGs) have emerged as a versatile therapeutic platform, owing to their unique structural advantages, including high drug encapsulation capacity, easy surface modification, stimuli‐responsiveness, and excellent biosafety, collectively addressing critical limitations of conventional immunotherapy delivery systems. Herein, the advances in functional NG design and synthesis for immunomodulation to treat cancer and inflammatory diseases are reviewed. The mechanisms of NGs in immunotherapy are mainly elucidated including immunotherapy factor delivery systems enabling precise payload release, the immune modulation through both activation and suppression, and targeting strategies at immune cell levels. Finally, the challenges and application prospects of NG‐based nanoplatforms in the treatment of cancer and inflammatory diseases are briefly discussed.