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October 2, 2025Advanced ScienceOpen Access

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

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Authors

HCHui ChenZLZhicong LiuQSQiang Shu

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Overview

This review uncovers how lineage tracing technologies enhance insights into cell fate determination, suggesting implications for regenerative medicine and disease advancement.

Key Points

  • Cell fate determination plays a key role in multicellular development, influencing tissue homeostasis and regeneration.
  • Lineage tracing technologies have evolved significantly, from manual observation to advanced genetic labeling techniques enabling single-cell tracking.
  • Investigating plasticity in cell differentiation pathways provides novel insights into disease pathogenesis and regenerative strategies.
  • Understanding the tissue microenvironment's role in cell fate decisions is increasingly critical for advancements in regenerative medicine.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1b78dhttps://doi.org/10.1002/advs.202507183
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  4. 4Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage Modeling2025
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