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September 30, 2025HLA

The Novel HLA‐C*15:02:01:66 Allele Identified Through Next‐Generation Sequencing in a Greek Individual

Diamanto Kouniaki Georgia Galaziou Alexandra Tsirogianni

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Key Points

hla-c*15:02:01:66 shows a single-nucleotide substitution compared to hla-c*15:02:01:01.
The allele was discovered through next-generation sequencing in a Greek individual.
Understanding this genetic variation can aid in population health and disease susceptibility research.
This finding enhances the knowledge about hla-c alleles and their variations in different populations.

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Implication

Novel allele hla-c*15:02:01:66 was identified in a Greek individual, suggesting genetic diversity in hla-c genes.

Abstract

The HLA‐C*15:02:01:66 allele differs from HLA‐C*15:02:01:01 by a single‐nucleotide substitution in Intron 6.

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Cite This Study

Kouniaki et al. (2025) studied this question.

synapsesocial.com/papers/68de84bf5b556a9128e1bd52 https://doi.org/10.1111/tan.70416

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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2A novel <i>HLA‐C*01</i> variant, <i>HLA‐C*01:02:01:70</i>, identified in a healthy individual from Greece2024 · 6 citations
3Identification of the new allele <i>HLA‐C*04:01:01:186</i> in a Greek individual using next generation sequencing2024 · 3 citations
4The novel <i>HLA‐C*15:279</i> allele, identified by <scp>Sanger</scp> dideoxy nucleotide sequencing in a Chinese individual2024 · 3 citations
5Identification of a Novel <scp>HLA</scp> ‐A Allele, <i>HLA‐A*02:02:09</i> , Discovered by Next‐Generation SequencingOriginal Research · 2026 · 1 citations

The novel <scp>HLA</scp> class I allele <i>HLA‐C*07:02:81</i> differs from <i>HLA‐C*07:02:01:01</i> by a synonymous mutation2024
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A novel <i>HLA‐C*04</i> variant, <i>HLA‐C*04:01:01:174</i>, identified in a healthy individual from Greece2024
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