PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
October 3, 2025BMC MedicineOpen Access

Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes

View Full Paper
Ask AI
Bookmark
Share

Authors

CPClaire PrinceLHLaura D HoweESEleanor Sanderson

Discussion

Loading...

Member takes

Overview

Observational analysis shows parity influences breast cancer risk in women, suggesting caution in interpretations.

Key Points

  • Limited evidence suggests a protective effect of earlier age at first birth on breast cancer risk.
  • The odds ratio for later age at first birth reducing ER-negative breast cancer risk was 0.76 before adjustments.
  • Multivariable analysis indicated weak associations, likely due to limitations from weak instruments.
  • Findings suggest genetically correlated factors like age at menarche and menopause may confound results.

Cite This Study

Prince et al. (2025) studied this question.

synapsesocial.com/papers/68dfe935daa1363beb049a2ahttps://doi.org/10.1186/s12916-025-04375-6
View Full Paper
Ask AI
Bookmark
Share