Associations between triglyceride-glucose index in the early trimester of pregnancy and adverse pregnancy outcomes

Adverse pregnancy outcomes seriously affect the health of pregnant women and fetuses. However, no typical symptoms occur in the early trimester of pregnancy. The present study aimed to evaluate the predictive efficacy of the triglyceride-glucose (TyG) index in the early trimester for adverse pregnancy outcomes. A total of 2,847 singleton pregnant women without preconception diabetes and hypertension were included. The multivariate logistic regression model was used to explore the relationship between the TyG index and pregnancy adverse outcomes. TyG index in the early trimester of pregnancy was an independent risk factor for gestational diabetes mellitus (GDM) (OR = 2.16, 95%CI 1.63–2.87, P 8.167. The first-trimester TyG index is closely associated with the development of GDM and GH among pregnant women. An elevated TyG index in early trimester pregnancy may help predict the risk of GDM and GH, which provides an effective marker for us to prevent and detect adverse pregnancy outcomes in the early stage.