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Analysis reveals novel isoprenoids with cytotoxic effects against HepG2 and A549 cell lines.
Four new isoprenoids, dictamtriterpenols B-E (1-4), and fifteen known compounds (5-19) were isolated from Dictamnus dasycarpus Turcz. And the structures of all compounds were determined through techniques such as nuclear magnetic resonance spectroscopy. Compounds 1, 4, 7, 13, and 15 exhibited notable cytotoxic effects against HepG2 cells (IC50 1.55-18.55 μM). Similarly, compounds 1, 3, 8, 9, and 12 demonstrated significant cytotoxicity against A549 cells (IC50 1.63-8.56 μM).
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Sun et al. (2025) studied this question.
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