October 3, 2025eLifeOpen Access

Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

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Authors

YKYoshinori KohwiLawrence Berkeley National Laboratory XWXianrong WongJohns Hopkins University MGMari GrangeUniversity of California, San Francisco

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Overview

Observational analysis explores SATB1's role in chromatin organization and gene expression in thymocytes, suggesting a model for cell-specific transcription.

Key Points

In mouse thymocytes, SATB1 binding shapes chromatin architecture and promotes cell-type-specific gene expression, enhancing transcription.
Urea ChIP-seq revealed direct SATB1 binding to base-unpairing regions, while binding was less evident at CTCF sites, indicating target specificity.
Interaction of BURs with accessible chromatin spans multiple topologically associated domains, signifying a complex genomic architecture.
SATB1 forms a chromatin scaffold evident in transcriptionally repressive lamina-associated domains, with implications for cell-specific regulatory mechanisms.

Cite This Study

Kohwi et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1eab https://doi.org/10.7554/elife.105915.3

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October 3, 2025eLifeOpen Access

Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

View Full Paper

Ask AI

Bookmark

Authors

YKYoshinori KohwiLawrence Berkeley National Laboratory XWXianrong WongJohns Hopkins University MGMari GrangeUniversity of California, San Francisco

Discussion

Member takes

Overview

Observational analysis explores SATB1's role in chromatin organization and gene expression in thymocytes, suggesting a model for cell-specific transcription.

Key Points

In mouse thymocytes, SATB1 binding shapes chromatin architecture and promotes cell-type-specific gene expression, enhancing transcription.
Urea ChIP-seq revealed direct SATB1 binding to base-unpairing regions, while binding was less evident at CTCF sites, indicating target specificity.
Interaction of BURs with accessible chromatin spans multiple topologically associated domains, signifying a complex genomic architecture.
SATB1 forms a chromatin scaffold evident in transcriptionally repressive lamina-associated domains, with implications for cell-specific regulatory mechanisms.

Cite This Study

Kohwi et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1eab https://doi.org/10.7554/elife.105915.3

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