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October 3, 2025

SOX4-Mediated Post-Transcriptional suppression of PTEN via miR-106b~25 Cluster Contributes to Prostate Cancer Aggressiveness.

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Authors

FSFeifei SunLGLin GaoMWMeng Wang

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Overview

This study demonstrates SOX4 downregulates PTEN via miR-106b~25 in prostate cancer, suggesting new therapeutic targets.

Key Points

  • SOX4 high and PTEN low expression correlates with aggressive prostate cancer subtypes with poor prognosis.
  • Mechanistically, SOX4 downregulates PTEN via post-transcriptional modulation by activating miR-106b~25 cluster.
  • Dual targeting of SOX4 and PI3K-AKT signaling can effectively inhibit prostate cancer proliferation and invasion.
  • Findings highlight the importance of molecular risk stratification in guiding precision therapies for prostate cancer.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1f33https://doi.org/10.1158/1541-7786.mcr-25-0471
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer2024 · 9 citations
  2. 2Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study2011 · 822 citations
  3. 3CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX42019 · 28 citations
  4. 4ERG–SOX4 interaction promotes epithelial–mesenchymal transition in prostate cancer cells2014 · 62 citations
  5. 5Clinical, Pathological and Molecular Prognostic Factors in Prostate Cancer Decision-Making Process2016 · 15 citations