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October 3, 2025Frontiers in ImmunologyOpen Access

A long-term culture model for investigating senescence-associated dysregulation in macrophages

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In vitro observations reveal cytokine profile changes and immune dysfunction in macrophages, indicating senescence's role in aging.

Macrophages transition from anti-inflammatory to proinflammatory profiles over time, indicating dysregulation.
Significant upregulation of senescence markers occurs between days 7 and 21 in cultured macrophages.
High-dimensional flow cytometry identifies five distinct macrophage subpopulations, highlighting their loss of plasticity.
Day 7 macrophages demonstrate a diverse cytokine response to LPS, whereas later time points show a restricted profile.

Ruíz et al. (2025) studied this question.

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October 3, 2025Frontiers in ImmunologyOpen Access

View Full Paper

Ask AI

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Authors

In vitro observations reveal cytokine profile changes and immune dysfunction in macrophages, indicating senescence's role in aging.

Macrophages transition from anti-inflammatory to proinflammatory profiles over time, indicating dysregulation.
Significant upregulation of senescence markers occurs between days 7 and 21 in cultured macrophages.
High-dimensional flow cytometry identifies five distinct macrophage subpopulations, highlighting their loss of plasticity.
Day 7 macrophages demonstrate a diverse cytokine response to LPS, whereas later time points show a restricted profile.

Ruíz et al. (2025) studied this question.

View Full Paper

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