ABSTRACT Objective To evaluate the effects of maxillary sinus augmentation (MSA) using deproteinized bovine bone material (DBBM) combined with or without platelet‐rich fibrin obtained by horizontal centrifugation (H‐PRF) after a short healing period of 4 months. Materials and Methods Thirteen patients underwent bilateral two‐stage MSA using a split‐mouth model. Each side was randomly assigned to receive DBBM alone (control group) or DBBM + H‐PRF (test group). Bone tissue samples were harvested 4 months after implant placement and evaluated using microcomputed tomography (micro‐CT), as well as histological and histomorphometric analyses. Data were statistically analyzed using paired t ‐tests (Wilcoxon signed‐rank test; p < 0.05). Results Histomorphometric analysis demonstrated higher amounts ( p < 0.05) of newly formed bone in the DBBM + H‐PRF group compared to the control group (51.33% ± 6.17% versus 45.68% ± 6.65%, respectively). Micro‐CT also revealed significantly higher bone volume (30.38% ± 11.24% and 21.38% ± 9.83%, respectively) and connectivity density (4485 ± 1469 and 2562 ± 1271, respectively) in the DBBM + H‐PRF group than in the DBBM‐alone group ( p < 0.05). Conclusions Compared with DBBM alone, maxillary sinuses augmented with H‐PRF combined with DBBM exhibited improved qualitative and quantitative new bone formation after 4 months of healing. However, the effects on the long‐term survival and early stability of dental implants remain unknown and warrant further investigation with long‐term follow‐up.
Reis et al. (2025) studied this question.