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October 3, 2025Open Access

Analysis of a simple disk diffusion method to evaluate Ceftazidime-avibactam/Aztreonam combination synergism against NDM clinical isolates.

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Authors

RRReena RajanSGSasikala GopinathanARA. V. Raghavendra Rao

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Overview

Cross-sectional analysis confirms effectiveness of Ceftazidime-avibactam/Aztreonam synergy against NDM strains, implying potential for treating resistant infections.

Key Points

  • Ceftazidime-avibactam/Aztreonam showed synergy against 63.6% of carbapenem resistant isolates.
  • In total, 25 out of 39 NDM isolates exhibited synergy, indicating promising treatment potential.
  • Analysis utilized the disk diffusion method and involved 62 clinical isolates from 2022 to 2024.
  • Significant differences in inhibition zones reflect the potential advantage of combination therapy.

Cite This Study

Rajan et al. (2025) studied this question.

synapsesocial.com/papers/68e034fdf0e39f13e7fa3676https://doi.org/10.1099/acmi.0.001049.v2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessing the Synergistic Potential of Ceftazidime–avibactam and Aztreonam against Metallo-beta-lactamase Producing Enterobacterales by Disc Elution and Disc E Strip – Synergy Method2026
  2. 2IN VITRO SUSCEPTIBILITY COMPARISON OF AZTREONAM ALONG WITH CEFTAZIDIME-AVIBACTAM SYNERGY TESTING METHODS AND AZTREONAMAVIBACTAM AGAINST CARBAPENEM RESISTANT ORGANISMS IN ISOLATES OBTAINED FROM CANCER PATIENTS2025
  3. 3Evaluation of a simple method for testing aztreonam and ceftazidime-avibactam synergy in New Delhi metallo-beta-lactamase producing Enterobacterales2024 · 3 citations
  4. 4A Study on Ceftazidime/Avibactam and Aztreonam Synergy Among Aztreonam Resistant Metallo-β-lactamase Producing Enterobacterales in a Tertiary Care Hospital2024 · 1 citations
  5. 5Synergistic Effect of Ceftazidime-Avibactam with Aztreonam on Carbapenemase-Positive Klebsiella pneumoniae MBL+, NDM+ [Letter]2024