Potential Roles of PDE4 Inhibitors in Peptic Ulcer Treatment

Introduction. Peptic ulcer disease, a common gastrointestinal disorder, is mostly caused by Helicobacter pylori infection, non-steroidal anti-inflammatory drug usage, and lifestyle factors including alcohol use and smoking. Irsogladine, a non-specific selective PDE4 inhibitor, has demonstrated therapeutic potential in gastric ulcers by promoting mucosal healing, reducing inflammation, and enhancing antioxidant defenses. This review explores the therapeutic potential of irsogladine and PDE4B inhibitors in treating peptic ulcers. Methods. To find appropriate research for this review article, a thorough literature search was carried out utilizing electronic databases such as Google Scholar and PubMed. Keywords such as “peptic ulcer”, “Phosphodiesterase-4 inhibitors”, “irsogladine”, “cAMP” and “mucosal healing” were used in the search strategy. Only recent, English-language publications were included in the search. Conclusion. Phosphodiesterase-4 inhibitors, particularly those targeting phosphodiesterase -4B inhibitors, play a significant role in modulating immune responses, reducing oxidative stress, and supporting angiogenesis. These properties make them a promising therapeutic approach for peptic ulcer disease. Future research should focus on optimizing the selectivity of phosphodiesterase-4 inhibitors, evaluating their long-term safety, and conducting large-scale clinical trials to establish their efficacy in peptic ulcer management.