Two new phloroglucinols show significant cardioprotective activity in Hypericum monogynum, indicating potential benefits for heart health.
Six new phloroglucinols which were assigned as two pairs of natural enantiomer (±)-Harmansenoids A (1) and B (2) together with two known ones were separated from Hypericum monogynum L (Hypericaceae). The planer and stereochemical structure were elucidated by using NMR, HR-ESI-MS, ECD analysis and computational chemistry method. Further, the cardioprotective activity of all compounds were evaluated by MTT method. Among them, compound 3 exhibited the strongest effect than other isolates.
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Zhou et al. (2025) studied this question.
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