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October 3, 2025Journal of Nuclear Medicine

Resisting RECIST: PSMA PET and Regulatory Change in Prostate Cancer

Oliver Sartor Louise Emmett Ken Herrmann

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Key Points

PSMA PET imaging challenges the established RECIST guidelines for assessing response in prostate cancer.
RECIST, developed by key cancer organizations, outlines standardized measurement criteria for tumors.
Regulatory changes may influence the acceptance and implementation of new imaging techniques in clinical practice.
Adapting assessment criteria could enhance treatment evaluation and patient outcomes in prostate cancer management.

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Implication

Analysis highlights regulatory changes in prostate cancer and identifies the role of PSMA PET imaging.

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Cite This Study

Sartor et al. (2025) studied this question.

synapsesocial.com/papers/68e22da774308421369af010 https://doi.org/10.2967/jnumed.125.271144

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1RECIP 1.0 Predicts Progression-Free Survival After [<sup>177</sup>Lu]Lu-PSMA Radiopharmaceutical Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer2024 · 28 citations
2pRECIST: Guidelines for Response Criteria for Use in Trials Testing Therapeutics in Pancreatic CancerClinical Guideline · 2026
3Abstract PO4-06-03: A comparative study between RECIST 1.1 using MRI and PERCIST 1.0 using PET/CT to evaluate the response in patients of carcinoma breast receiving neoadjuvant chemotherapy2024
4Prognostic Performance of RECIP 1.0 Based on [<sup>18</sup>F]PSMA-1007 PET in Prostate Cancer Patients Treated with [<sup>177</sup>Lu]Lu-PSMA I&T2024 · 17 citations
5PSMA-PET response under [177Lu]Lu-PSMA therapy: Comparison of RECIST, PERCIST, PPP, adapted PCWG4 and RECIP criteriaRetrospective Study · 2026 · 1 citations

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EVALUATION OF TREATMENT RESPONSE IN SOLID TUMORS USING RECIST 1.1 CRITERIA: A RADIOLOGICAL STUDY2026

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