Observational analysis reveals that locus coeruleus norepinephrine disrupts extinction learning via the amygdala, indicating potential therapeutic targets.
Key Points
Activation of locus coeruleus noradrenergic neurons impairs extinction learning and alters vmPFC dynamics.
Selective chemogenetic activation of LC-BLA projections led to significant impairment in fear extinction learning.
Propranolol infusions into the amygdala mitigated the negative effects of locus coeruleus activation on vmPFC.
The study highlights the critical role of the amygdala as an interface mediating stress-induced extinction impairments.