Unraveling Risk Determinants in Avascular Necrosis: A Cross-Sectional Analysis of Demographic, Behavioral and Hemostatic Profiles

Avascular necrosis (AVN), or osteonecrosis, is a debilitating condition caused by reduced blood flow leading to bone tissue death. While commonly linked to trauma, corticosteroid use, and alcohol abuse, emerging evidence suggests that microvascular thrombosis and hypercoagulability may significantly contribute to its development. Prothrombotic condi-tions can obstruct bone microcirculation, resulting in tissue necrosis without infection or malignancy. This study explores the role of coagulation abnormalities as potential risk factors for AVN through a cross-sectional, observational, and analytical approach. A total of 28 patients with non-traumatic osteonecrosis were recruited from a tertiary care center. Each underwent comprehensive coagulation testing to assess thrombotic risk. The study also analyzed demographic and behavioral factors such as age, sex, alcohol intake, and smoking. Preliminary results revealed a high incidence of procoagulant abnormalities, supporting the theory that impaired hemostasis may underlie ischemic bone damage. These findings highlight the importance of including coagulation profiles in the diagnos-tic and prognostic assessment of AVN, promoting a more integrative approach to manag-ing patients at risk for this condition.