Case series shows significant visual acuity gains in three CSCR patients treated with spironolactone, indicating its therapeutic potential.
Purpose: To describe clinical outcomes of spironolactone therapy in patients with central serous chorioretinopathy (CSCR). Methods: We present a case series of three male patients diagnosed with CSCR and treated with oral spironolactone 25 mg/day for three months. All patients underwent baseline and follow-up ophthalmologic evaluation, including uncorrected visual acuity (UCVA) and optical coherence tomography (OCT). Results: All three patients showed significant anatomical and functional improvements. UCVA improved from 6/40 to 6/15 in Case 1, from 6/40 to 6/7.5 in Case 2, and from 6/40 to 6/8 in Case 3. OCT demonstrated near-complete resorption of subretinal fluid in all cases. No systemic or ocular adverse effects were reported during treatment. Conclusion: Low-dose spironolactone was effective and well tolerated in CSCR, supporting its potential as a therapeutic option in both acute and persistent cases.
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Fricella et al. (2025) studied this question.
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