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This case report highlights diagnostic challenges of histiocytic sarcoma, suggesting the need for thorough evaluations in symptomatic patients.
We report a 31‐year‐old male patient repeatedly hospitalized for mimicking infectious symptoms. Following standardized anti‐infective and anti‐inflammatory treatment, clinical evolution was discordant, characterized by treatment non‐response and symptom exacerbation. Ultimately, the multidisciplinary team and repeated histopathological examinations diagnosed histiocytic sarcoma (HS). Unfortunately, the treatment opportunity was lost due to HS's high aggressiveness and rapid progression.
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Zhang et al. (2025) studied this question.
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