This research finds a method for C(sp3)-H functionalization in barbituric acids, suggesting it offers a greener alternative using organophotocatalysis.
This study presents a sustainable and efficient visible‐light‐driven organophotocatalytic strategy for transforming the methylene carbon of barbituric acids into valuable hydrazones and spirocyclic products. The reaction proceeds smoothly under mild conditions by utilizing eosin Y as a green photocatalyst and atmospheric oxygen as the sole oxidant. This method provides an environmentally friendly alternative to traditional approaches and offers intriguing mechanistic insights into umpolung C(sp3)‐H functionalization, thereby paving the way for novel reactivity in barbiturate chemistry.
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Nath et al. (2025) studied this question.
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