Case report highlights discordance between imaging metrics and histopathology in pancreatic NET, suggesting the importance of dual-tracer PET/CT.
Neuro endocrine tumors (NETs) demonstrate complex biology where imaging and histology can at times show discordance in a real-world scenario. We herein present a patient of grade I pancreatic NET showing atypical low somatostatin receptor expression on 68Ga-DOTATATE PET/CT (positron emission tomography/computed tomography) but intense fluorine-18-deoxyglucose (18FDG) avidity, and when interpreted together, these findings showed discordance with histopathology. The case highlights the crucial role of dual-tracer PET/CT in navigating the tumor biology and landscape of NET and the need for novel strategies to complement traditional histopathology that would enable better therapeutic decision-making.
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Shah et al. (2025) studied this question.
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