Molecular analysis reveals how amino acids in loops C and D dictate nicotinic ligand selectivity across insect and mammalian receptors, highlighting mechanisms for species-selective design.
This investigation defines the roles of various amino acids, neighboring key conserved amino acids in loops C and D of the nicotinic acetylcholine (ACh) receptor (nAChR), in the selective molecular recognition of nicotinic ligands with diverse pharmacophores using
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Terajima et al. (2024) studied this question.
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