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October 2, 2024ACS Medicinal Chemistry Letters

Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies

Silvia Salerno Elisabetta Barresi Michele Roggia Benito Natale Simona Marzano Mariafrancesca Hyeraci Serena Concetta Rita Reina Emma Baglini Jussara Amato Erica Salvati Lisa Dalla Via Federico Da Settimo Sandro Cosconati Sabrina Taliani

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Abstract

Here, we explored the benzothiopyranoindole scaffold to develop antiproliferative agents with a polypharmacological profile targeting both G-quadruplex (G4)-structures and Topoisomerase (Topo) I enzyme. In a preliminary optimization phase, compound

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Salerno et al. (2024) studied this question.

synapsesocial.com/papers/68e55ffce2b3180350efced9 https://doi.org/10.1021/acsmedchemlett.4c00313

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