Expression of CSC markers in colorectal cancer. A and B, Representative confocal images of two colorectal cancer tumors showing CSC marker–expressing cells; cyan, LGR5; green, CD90; red, EpCAM; blue, DAPI (nuclear marker). Arrowheads indicate colocalization. C and D, Left two plots, representative flow cytometric plots depicting the percentage of AF- and LGR5-positive cells in two colorectal cancer tumors. Control tube, only secondary A546 added. Right two plots, analysis of the percentage of LGR5+ cells inside the AF+ population and vice versa.
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Alcalá et al. (2024) studied this question.
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