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October 1, 2024Infection and Drug ResistanceOpen Access

Lack of Resistance Mutations to the Novel HIV-1 Capsid Inhibitor Lenacapavir Among People Living with HIV in Guangdong, China

Yaqing Lin Xuemei Ling Linghua Li Ruolei Xin Fengyu Hu Junbin Li Jiaojiao Li Feng Li Yun Lan

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Abstract

The capsid inhibitor (CAI) lenacapavir (LEN) was approved for use in 2022, yet there are few reports about its drug resistance mutations (DRMs) and sensitivity.

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Cite This Study

Lin et al. (2024) studied this question.

synapsesocial.com/papers/68e56113e2b3180350efd8a3 https://doi.org/10.2147/idr.s484383

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A Review of Lenacapavir Act as Caspid Inhibitor2025 · 1 citations
2Natural occurrence of drug resistance mutations to the <scp>HIV</scp>‐1 capsid inhibitor lenacapavir2025 · 4 citations
3Cross-resistance to entry inhibitors and lenacapavir resistance through Week 52 in study CAPELLAEarly-Phase Clinical Trial · 2023 · 23 citations
4Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis2025 · 18 citations
5Recurrent and novel evolutionary pathways drive in vitro HIV-1 lenacapavir resistance with diverse phenotypic consequencesIn Vitro Study · 2026 · 2 citations

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Lenacapavir: a transformative advance in HIV therapy and prevention—promise, access, and equity in Africa2026

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