Randomized double-blind trial reports tolerability and efficacy of nicotinamide combined with antioxidants in women with facial melasma, highlighting alternative non-hydroquinone regimens.
Nicotinamide has demonstrated efficacy in the treatment of melasma. Topical antioxidants and humectants may enhance its performance. Currently, there is no controlled trial on the combination of 10% nicotinamide, 5% magnesium ascorbyl phosphate, and 5% hyaluronic acid, a dermo-cosmetic compound, in comparison to 4% hydroquinone for the treatment of melasma. This study aimed to explore the tolerability and efficacy of the association of the combined product
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Barbosa et al. (2024) studied this question.
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