Key points are not available for this paper at this time.
Drug therapy of older and senile patients has several features due to age-related changes in the pharmacokinetics and pharmacodynamics of drugs, as well as the nature of the development and course of the disease. Age-related changes in drug pharmacodynamics, and increased or decreased sensitivity to drugs of different pharmacotherapeutic groups significantly affect the drug effectiveness and safety in the body. These peculiarities must be considered when prescribing pharmacotherapy for elderly and senile patients, and adjusting doses and regimens of drug administration. Morbidity in older people is characterised by a high level of polymorbidity and polypharmacy caused by it. When prescribing medicine to older patients, it has to observe all indications and contraindications. The drug interaction problem, which can increase the side effects risk, requires special attention under the conditions of age-related polymorbidity and polypharmacy. To optimise the metabolism and functions of the body, it is advisable to include metabolic therapy drugs in the older patients' complex therapy. Adherence to the rules for prescribing medicines according to the age-related features of their action is an important prerequisite for rational pharmacotherapy of older and senile patients. _________________________________________________________________________________________ Keywords: pharmacotherapy in ageing; pharmacokinetics; drug pharmacodynamics; polymorbidity; polypharmacy
Kuprash et al. (Sun,) studied this question.