Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

Yusuke Goto; Keiichi Koshizuka; Toshinori Ando; Hiroki Izumi; Xingyu Wu; Kuniaki Sato; Tomohiko Ishikawa; Kyle Ford; Xiaodong Feng; Zhiyong Wang; Nadia Arang; Michael M. Allevato; Ayush Kishore; Prashant Mali; J. Silvio Gutkind

doi:10.1158/2767-9764.27128832

September 28, 2024

Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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Key Points

Targeting the cell cycle pathway induces synthetic lethality alongside mTOR inhibition, which prevents adaptive resistance to CDK4 and CDK6 blockade.
CRISPR screening across kinome-wide targets maps synthetic lethal interactions in head and neck squamous cell carcinoma cell models lacking sensitivity.
Preclinical cell model findings highlight combined cell cycle and mTOR pathway inhibition, though validation in vivo and clinical cohorts is required.

Implication

CRISPR screen reveals cell cycle pathway as synthetic lethal partner for mTOR inhibition in HNSCC, suggesting dual blockade prevents adaptive resistance.

Abstract

CRISPR screening identified cell cycle pathway as synthetic lethal pathway for mTORi in HNSCC

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Cite This Study

Goto et al. (2024) studied this question.

synapsesocial.com/papers/68e57186b6db643587512415 https://doi.org/10.1158/2767-9764.27128832

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Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 1 from A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

Key Points

Implication

Abstract

Discussion

Cite This Study

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