Enhanced Antibacterial Activity of Levofloxacin with Cucurbit[7]uril-Functionalized Gold Nanoparticles

Bacterial infection is one of the major concerns of the growing society, and over the years, different permutations and combinations of various drugs and adjuvants have been attempted, which led to considerable improvements in the efficacy of the antibacterial drugs. In this regard, macrocyclic receptors such as cyclodextrin, cucurbiturils, calixarene, etc., have played a major role by modulating the drug properties that supplement the antibacterial efficacy. In this study, we have developed cucurbit[7]uril (CB7)-functionalized Au nanoparticles (CB7AuNPs) to modulate the activity of an antibiotic, levofloxacin (LOFL). From the spectroscopic and thermodynamic changes in the LOFL, it has been established that two of the prototropic forms, LOFLH and LOFLH