Figure 8 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma

SREBP pathway is broadly required for cancer cell growth and is activated in human PDAC tumors. A–C, The essentiality of SCAP, SREBF1, and SREBF2 across cancer cell lines was examined using the Cancer Dependency Map project database (Public Chronos 23Q4). The mean Chronos dependency scores are shown for multiple organ systems, including the pancreas (red). Negative scores indicate gene essentiality. D, Expression of SREBP target genes in PDAC tumor tissue compared with normal tissue is shown from two Oncomine data sets Pei and Badea (33). Blue, lower gene expression; red, higher gene expression; black, P > 0.05. Genes are grouped and color-coded by bioinformatic process (https://www.genepattern.org/#gsc.tab=0). E, The association of SREBP target genes with survival from patients with PDAC was queried using the Kaplan–Meier Plotter tool (https://kmplot.com/analysis/) and RNA sequencing datasets (n = 177 patients for each curve).