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Larock isoquinoline synthesis is one of the most efficient and straightforward approaches to the construction of 3,4-disubstituted isoquinolines. However, there have been no asymmetric versions for the synthesis of axially chiral isoquinolines since their initial report in 2001. Herein, we documented the first example of an asymmetric Larock isoquinoline synthesis by employing Pd(OAc)
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Wang et al. (2024) studied this question.
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