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September 25, 2024Frontiers in ImmunologyOpen Access

Differential expression of HIV target cells CCR5 and α4β7 in tissue resident memory CD4 T cells in endocervix during the menstrual cycle of HIV seronegative women

Sakthivel Govindaraj Staple Tyree Gina Bailey Herring Sadia J. Rahman Hemalatha Babu Chris Ibegbu M. R. Young C. Christina Mehta Lisa B. Haddad Alicia K. Smith Vijayakumar Velu

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Abstract

Ovarian hormones are known to modulate the immune system in the female genital tract (FGT). We sought to define the impact of the menstrual cycle on the mucosal HIV target cell levels, and tissue-resident CD4 T cells.

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Cite This Study

Govindaraj et al. (2024) studied this question.

synapsesocial.com/papers/68e57665b6db643587516723 https://doi.org/10.3389/fimmu.2024.1456652

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of womenOriginal Research · 2026
2HIV ‐1 co‐receptor expression and epithelial immune cells of the cervix in asymptomatic women attending a genitourinary medicine clinicOriginal Research · 2012 · 6 citations
3Phenotype and Functionality of <scp>CD</scp>4<sup>+</sup> and <scp>CD</scp>8<sup>+</sup> T Cells in the Upper Reproductive Tract of Healthy Premenopausal WomenOriginal Research · 2013 · 41 citations
4Mucosal Dynamics Contributing to Innate Immune Responses to HIV in the Human Female Genital TractReview · 2026
5T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV InfectionReview · 2026 · 1 citations

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Spatial transcriptomics and in situ immune cell profiling of the host ectocervical landscape of HIV infected Kenyan sex working women2024
No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study2025
Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women2022

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