⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

September 25, 2024EMBO ReportsOpen Access

Kinesin-1 mediates proper ER folding of the CaV1.2 channel and maintains mouse glucose homeostasis

Yosuke Tanaka Atena Farkhondeh Wenxing Yang Hitoshi Ueno Mitsuhiko Noda Nobutaka Hirokawa

View Full Paper

Ask AI

Bookmark

Share

Abstract

Glucose-stimulated insulin secretion (GSIS) from pancreatic beta cells is a principal mechanism for systemic glucose homeostasis, of which regulatory mechanisms are still unclear. Here we show that kinesin molecular motor KIF5B is essential for GSIS through maintaining the voltage-gated calcium channel Ca

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Tanaka et al. (2024) studied this question.

synapsesocial.com/papers/68e5766bb6db643587516b95 https://doi.org/10.1038/s44319-024-00246-y

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Kinesin-1 mediates proper ER folding of the CaV1.2 channel and maintains mouse glucose homeostasis2024
2Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studiesReview · 2026 · 1 citations
3[Ca<sup>2+</sup>]<sub>i</sub> regulates trafficking of Ca<sub>v</sub>1.3 (α<sub>1D</sub> Ca<sup>2+</sup> channel) in insulin-secreting cellspreclinical · 2004 · 23 citations
4KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes2024 · 8 citations
5A Novel Mechanism for the Suppression of a Voltage-gated Potassium Channel by Glucose-dependent Insulinotropic Polypeptidepreclinical · 2005 · 42 citations