Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Overexpression of Toxic Poly(Glycine-Alanine) Aggregates in Primary Neuronal Cultures Induces Time-Dependent Autophagic and Synaptic Alterations but Subtle Activity Impairments2024 · 4 citations
2. 2Poly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons2024 · 23 citations
3. 3C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD2024 · 12 citations
4. 4<i>C9orf72</i><scp>ALS</scp>‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules2025 · 3 citations
5. 5C9orf72-ALS mutation drives basal mitophagy impairments in iNeuronsOriginal Research · 2026 · 1 citations